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P H Krammer Selected Research

Fas Ligand Protein (Fas Ligand)

9/2015Induction of apoptosis by IFNγ in human neuroblastoma cell lines through the CD95/CD95L autocrine circuit.
9/2009Rocaglamide sensitizes leukemic T cells to activation-induced cell death by differential regulation of CD95L and c-FLIP expression.
7/2004Enhanced caspase-8 recruitment to and activation at the DISC is critical for sensitisation of human hepatocellular carcinoma cells to TRAIL-induced apoptosis by chemotherapeutic drugs.
10/2001Induction of apoptosis in 9-nitrocamptothecin-treated DU145 human prostate carcinoma cells correlates with de novo synthesis of CD95 and CD95 ligand and down-regulation of c-FLIP(short).
7/2001CCNU-dependent potentiation of TRAIL/Apo2L-induced apoptosis in human glioma cells is p53-independent but may involve enhanced cytochrome c release.
7/2001Therapeutic neutralization of CD95-ligand and TNF attenuates brain damage in stroke.
3/2001CD95 ligand-expressing tumors are rejected in anti-tumor TCR transgenic perforin knockout mice.
12/2000Proteasome inhibitor-induced apoptosis of glioma cells involves the processing of multiple caspases and cytochrome c release.
10/2000A novel AP-1 element in the CD95 ligand promoter is required for induction of apoptosis in hepatocellular carcinoma cells upon treatment with anticancer drugs.

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P H Krammer Research Topics

Disease

12Neoplasms (Cancer)
01/2014 - 01/2000
4Hepatocellular Carcinoma (Hepatoma)
01/2014 - 10/2000
2T-Cell Leukemia (Leukemia, T Cell)
02/2011 - 09/2001
2Carcinoma (Carcinomatosis)
10/2001 - 09/2001
2Glioma (Gliomas)
07/2001 - 12/2000
1Neuroblastoma
09/2015
1Hypoxia (Hypoxemia)
12/2014
1Leukemia
07/2011
1Adult T-Cell Leukemia-Lymphoma (Leukemia Lymphoma, T Cell, Acute, HTLV I Associated)
02/2011
1Dermatomyositis (Dermatopolymyositis)
12/2010
1Necrosis
07/2004
1Lymphoproliferative Disorders (Lymphoproliferative Disorder)
12/2001
1Asthma (Bronchial Asthma)
12/2001
1Eosinophilia
12/2001
1Experimental Liver Neoplasms
10/2001
1Stroke (Strokes)
07/2001
1Ischemia
07/2001
1Infarction (Infarctions)
07/2001
1Infections
06/2001
1Small Cell Lung Carcinoma (Small Cell Lung Cancer)
12/2000
1Breast Neoplasms (Breast Cancer)
08/2000
1Squamous Cell Carcinoma (Epidermoid Carcinoma)
02/2000
1Burkitt Lymphoma (Burkitt's Lymphoma)
01/2000
1Uterine Cervical Neoplasms (Cancer of the Cervix)
01/2000

Drug/Important Bio-Agent (IBA)

9Fas Ligand Protein (Fas Ligand)IBA
09/2015 - 10/2000
5Death Domain ReceptorsIBA
12/2005 - 01/2000
5LigandsIBA
09/2001 - 01/2000
4Caspase 8 (Caspase-8)IBA
07/2004 - 01/2000
3rocaglamideIBA
01/2014 - 09/2009
3Pharmaceutical PreparationsIBA
09/2009 - 06/2000
3Cytochromes c (Cytochrome c)IBA
10/2001 - 12/2000
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
07/2001 - 06/2000
3Interleukin-2 (IL2)IBA
06/2001 - 01/2000
2TNF-Related Apoptosis-Inducing LigandIBA
07/2004 - 03/2001
2AntibodiesIBA
09/2001 - 07/2001
1Proteins (Proteins, Gene)FDA Link
12/2014
1PhytochemicalsIBA
01/2014
1Reactive Oxygen Species (Oxygen Radicals)IBA
01/2014
1RNA (Ribonucleic Acid)IBA
07/2011
1FlavonesIBA
07/2011
1Apoptosis Regulatory ProteinsIBA
07/2011
1wogoninIBA
07/2011
1CytokinesIBA
12/2010
1Interleukin-5 (Interleukin 5)IBA
12/2001
1Tosyllysine Chloromethyl KetoneIBA
10/2001
1rubitecanIBA
10/2001
1Ethanol (Ethyl Alcohol)IBA
10/2001
1Type I DNA Topoisomerases (Topoisomerase I)IBA
10/2001
1EnzymesIBA
10/2001
1Peptide Hydrolases (Proteases)FDA Link
10/2001
1Thymidine KinaseIBA
10/2001
1Interleukin-4 (Interleukin 4)IBA
09/2001
1TNF-Related Apoptosis-Inducing Ligand ReceptorsIBA
07/2001
1Lomustine (CCNU)FDA Link
07/2001
1PerforinIBA
03/2001
1Indicators and Reagents (Reagents)IBA
03/2001
1Proteasome InhibitorsIBA
12/2000
1benzyloxycarbonylleucyl-leucyl-leucine aldehydeIBA
12/2000
1CaspasesIBA
12/2000
1Proteasome Endopeptidase Complex (Proteasome)IBA
12/2000
1lactacystinIBA
12/2000
1ElementsIBA
10/2000
1Transcription Factor AP-1 (Transcription Factor AP 1)IBA
10/2000
1Antineoplastic Agents (Antineoplastics)IBA
10/2000
1Etoposide (VP 16)FDA LinkGeneric
06/2000
1CASP8 and FADD-Like Apoptosis Regulating Protein (FLIP-S)IBA
02/2000
1Interleukin-7 (Interleukin 7)IBA
01/2000

Therapy/Procedure

5Drug Therapy (Chemotherapy)
01/2014 - 06/2000
3Therapeutics
02/2011 - 10/2001
1Organ Transplantation
10/2001
1Chemoradiotherapy
07/2001
1Aftercare (After-Treatment)
02/2000
1Immunotherapy
01/2000